Barn og ungdom Barn underneath 18 år skal ikke ta dette legemidlet. Andre legemidler og Modiodal: Snakk med lege eller apotek dersom du bruker, nylig har brukt eller planlegger å bruke andre legemidler. Modiodal og visse andre legemidler kan påvirke hverandre, og legen din kan trenge å justere dosene du tar.

carbamazepine will lessen the level or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

EMA ble opprettet i 1995 for å sikre ideal mulig utnyttelse av Europas vitenskapelige ressurser for evaluering av, tilsyn med og overvåkning av legemidler.

Scientific studies also propose that modafinil is a good procedure for both equally the tiredness and memory impairment connected to various sclerosis.‍[27]

Use modafinil all through pregnancy with caution if Rewards outweigh challenges. Animal studies clearly show hazard and human reports are usually not accessible, or neither animal nor human scientific studies were being completed.

Keep an eye on Carefully (1)modafinil will raise the degree or impact of flibanserin by influencing hepatic enzyme CYP2C19 metabolism.

Modafinil can be a wakefulness-marketing agent with confirmed nootropic properties. Its success has actually been effectively-documented in dozens of research over many years of analysis, and It is typically made use of off-label by balanced individuals who want to improve their mental efficiency.

modafinil will boost the level or result of clobazam by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Dosage adjustment may be necessary; CYP2C19 inhibitors may possibly end in greater publicity to N-desmethylclobazam (Lively metabolite).

nelfinavir will website enhance the amount or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

We found only two neuroimaging experiments inspecting the results of modafinil (Ellis et al 1999; Spence et al 2005) the two of which utilized Daring fMRI to look at occasion-associated circulatory variations from the brain. These two experiments are quite various in their technique and populace, but they both equally showed that modafinil seems to modulate as an alternative to unilaterally alter function-associated cortical blood circulation alterations, for in the two scientific studies modafinil’s effect on celebration-associated cortical blood move adjustments is negatively correlated to baseline event-relevant cortical blood flow transform. Notably, the research involving schizophrenic topics measured function related alterations in a Performing memory job, even though the study comparing narcoleptic and ordinary subjects calculated party-similar improvements throughout sensory stimulation.

Dose adjustments of such medicines and various medications that are substrates for CYP2C19 could possibly be necessary if modafinil is coadministered

Also, its medication pointers must be revised since experiments around the dose and frequency of modafinil have revealed diverse final results under various simulations, and armodafinil, that's confirmed to generally be far more Protected and effective, has actually been commercialized like a substituent of modafinil.

Avoid or substitute Yet another drug for these prescription drugs when probable. Evaluate for loss of therapeutic impact if medication has to be coadministered.

Melding av bivirkninger Kontakt lege, apotek eller sykepleier dersom du opplever bivirkninger. Dette gjelder også bivirkninger som ikke er nevnt i pakningsvedlegget. Du kan også melde fra om bivirkninger direkte by using meldeskjema som finnes på nettsiden til Direktoratet for medisinske produkter: ​/​pasientmelding. Ved å melde fra om bivirkninger bidrar du med informasjon om sikkerheten ved bruk av dette legemidlet. Les avsnitt 5. Hvordan du oppbevarer Modiodal Oppbevares utilgjengelig for barn. Bruk ikke dette legemidlet etter utløpsdatoen som er angitt på gjennomtrykksfolien og kartongen etter «EXP».